An important mechanistic result of this work is the documentation that Muc5b production is to certain extent dependent on STAT6/FoxA2 pathway and that pharmacological intervention of the STAT6/FOXA2 pathway, as has been previously proposed33, can serve as a mechanism for modulation of mucus during Pneumocystis infection. The gene discussed is MUC5B; the disease is Pneumocystis infectious disease.