Moreover, we found 7 VPFIs within 5 disease-associated genes in hypercholesterolemia, including ABCA1, APOB, LIPC, EPHX2, and PON2 genes, two of them directly associated to LDL levels (rs1367117 in APOB)43 and to ischemic stroke (rs751141 in EPHX2)44. Here, PON2 is linked to familial hypercholesterolemia.