APOB and familial hypercholesterolemia: Moreover, we found 7 VPFIs within 5 disease-associated genes in hypercholesterolemia, including ABCA1, APOB, LIPC, EPHX2, and PON2 genes, two of them directly associated to LDL levels (rs1367117 in APOB)43 and to ischemic stroke (rs751141 in EPHX2)44.