VPFIs included the rs1801133 variant in the MTHFR gene associated with gastric cancer in Chinese population41, the rs1800566 variant in the NQO1 gene, reported as a risk factor in digestive tract cancer in Asian and Caucasian populations42 and the rs11887534 variant in the ABCG8 gene, recently associated with gallbladder cancer in Chilean and HUI cohorts26. The gene discussed is NQO1; the disease is gallbladder cancer.