MTHFR and gallbladder cancer: VPFIs included the rs1801133 variant in the MTHFR gene associated with gastric cancer in Chinese population41, the rs1800566 variant in the NQO1 gene, reported as a risk factor in digestive tract cancer in Asian and Caucasian populations42 and the rs11887534 variant in the ABCG8 gene, recently associated with gallbladder cancer in Chilean and HUI cohorts26.