Additionally, SAPC-1-L cells that harbor a PTEN mutation (E288 frame shift/Y68 frame shift) were resistant to docetaxel, exhibiting a dose-dependent reduction with a high drug IC50 value of 105.8 ng/ml, which suggests that the Y68 frame shift mutation of PTEN may be associated with docetaxel resistance in endometrial cancer cells. The gene discussed is PTEN; the disease is endometrial cancer.