In osteosarcoma cells, miR-302a inhibits cell migration and invasion by directly targeting IGF-1R, and miR-302a can target GAB2, CXCR4, SDF1, Cyclin A, and Cyclin D to suppress cell proliferation, migration and invasion in glioma12,14,31,32. This evidence concerns the gene CCNA2 and osteosarcoma.