AKT1 and early-onset autosomal dominant Alzheimer disease: This result is supported by Liu, who demonstrated that the basal level of PI3K/Akt-dependent signalling was increased in diet-induced insulin resistance22, which is a key component of multiple metabolic diseases, such as metabolic syndrome, type 2 diabetes mellitus, atherosclerotic heart and brain disorders, fatty liver, Alzheimer’s disease, some types of cancer, and aging23–31.