Marfan syndrome (MFS) is an autosomal dominant disorder of connective tissue characterized by defects in the cardiovascular, pulmonary, skeletal, and ocular systems, with a frequency of approximately 1 in 3,000–5,000; caused by mutations in a gene that codes for fibrillin-1 (FBN1)1–3. This evidence concerns the gene FBN1 and Marfan syndrome.