Consistently, overexpressing Keap14A, but not Keap1WT or Keap14D also profoundly downregulated the Nrf2 protein levels, as well as the mRNA and protein levels of Nqo1 or Ho-1 genes, in Raw264.7 cells with E. coli infection (Fig. 7j, k). The gene discussed is HMOX1; the disease is escherichia coli infection.