Cholinergic Receptor Nicotinic Alpha subunits 6 and 2 (CHRNA6 UKBB-AC P = 7.60 × 10−3; CHRNA2 PGC-AD P = 1.4 × 10−2), Meningioma 1 (MN1, PGC-AD P = 9.1 × 10−3) and Hyaluronan And Proteoglycan Link Protein 1 (HAPLN1, UKBB-AC P = 1.9 × 10−2) are some exmples where differntialy expressed genes in thistle 2 module also showed some evidence of genetic contribution towards alcohol consumption or dependence. The gene discussed is CHRNA2; the disease is substance dependence.