The present study provides a systematic analysis of all available case–control studies on the CYP1A1 rs1048943 and rs4646903; and CYP1B1 rs1056836, rs10012, rs162549, rs1056827, rs1056837, rs1800440, rs2551188, and rs2567206 polymorphisms and the risk of PCa. Here, CYP1B1 is linked to posterior cortical atrophy.