In addition, PDAC patients with neoplasms of histologic grade G3-4 had significantly higher BUB1B, CCNA2, and CDC20 levels than those with grade G1-2 neoplasms (all P<0.05, Figure 8A), and high levels of BUB1B and CDC20 contributed to tumor formation (both P<0.05, Figure 8B). Here, CCNA2 is linked to neoplasm.