Intriguingly, this analysis established that WT HSPCs from patients with MPN were transcriptionally distinct from normal donor HSPCs (Figure 4A) and showed enrichment of inflammatory pathways associated with tumor necrosis factor α (TNFα) and interferon (IFN) signaling (Figures 3D, 3F, and 4B). Here, IFNA1 is linked to myeloproliferative neoplasm.