ADQ specifically bound the 36G46A site in the 5′ functional domain of HOTAIR (Fig. 4) and efficiently disrupted the interaction between HOTAIR and EZH2 both in vitro and in orthotopic tumor mouse models, thereby reducing the H3K27-mediated tri-methylation of NLK and consequently inhibiting tumor metastasis (Fig. 7). Here, NLK is linked to neoplasm.