Sarcoglycanopathies comprise four subtypes of autosomal recessive limb-girdle muscular dystrophy (LGMD2C, LGMD2D, LGMD2E, and LGMD2F) that are caused, respectively, by mutations in the SGCG, SGCA, SGCB, and SGCD genes, which encode four transmembrane glycoproteins, i.e., γ-sarcoglycan (SG), α-SG, β-SG, and δ-SG [1]. The gene discussed is SGCB; the disease is autosomal recessive limb-girdle muscular dystrophy type 2E.