Our simulation results suggest that one possible reason might be the impairment of PC pathway because of cancer, cancer treatment, etc. It is important to note that the current study cannot compare the significance of TM with other potentially important proteins such as t-PA, u-PA, PAI-1, PAI-2, TF and CP, in RA-induced improvement of clotting disorders in cancer patients. The gene discussed is SERPINB2; the disease is cancer.