Two international, multi-center phase I clinical trials of the off-the-shelf UCART19 cells in adults (from 16 to < 70 years, NCT02746952, CALM study) and pediatric (from 6 months to < 18 years, NCT02808442, PALL study) patients with R/R CD19+ALL have been initiated. The gene discussed is CD19; the disease is acute lymphoblastic leukemia.