In the TCGA dataset, 16 lncRNAs (WWC2-AS2, WEE2-AS1, TRHDE-AS1, PGM5-AS1, NR2F1-AS1, MEG3, LINC00667, LINC-PINT, HCG11, HAND2-AS1, GRIK1-AS1, FTX, FAM66C, EPB41L4A-AS2, CYP1B1-AS1 and ACVR2B-AS1) exhibited significantly downregulated expression in cancer tissue compared to normal tissue, consistent with the breast cancer expression model (Fig. 2a). The gene discussed is HAND2; the disease is breast cancer.