EPB41L4A and cancer: Next, EPB41L4A-AS2 was selected to validate the histone methylation modification model, as we first reported the potential function of EPB41L4A-AS2 in human cancer [16], and an obvious H3K27me3 enrichment peak at the EPB41L4A-AS2 locus could be observed in MDA-MB-231 cells (Fig. 5b).