Different autophagy deficient mice models such as Atg16L1 deficient chimeric mice, myeloid Atg16L1 deficient mice, colonic epithelial cell-specific Atg7 conditional KO mice, and Atg4B null mice all exhibit exacerbated colitis induced by DSS [34, 63, 64, 103]. Here, ATG16L1 is linked to colitis.