The results included a total of 13 articles based on 1922 PCOS patients and 1665 controls, showed that VDR ApaI (rs7975232) and VDR BsmI (rs1544410) polymorphisms are associated with PCOS susceptibility and VDR TaqI (rs731236), VDR FokI (rs2228570), VDR Tru9I (rs757343) did’t reveal a relationship with the PCOS susceptibility. The gene discussed is VDR; the disease is polycystic ovary syndrome.