The result showed that diabetes mellitus (DM) in first−/second−/third-degree relatives (OR = 0.266, P = 0.033) was the protective factor of positive β2-GPI antibody while DM (OR = 2.768, P = 0.001) and common bile duct stricture (OR = 2.952, P = 0.007) were the risk factors. The gene discussed is APOH; the disease is diabetes mellitus.