Previous study had demonstrated that β2-GPI could interact with oxidized low density lipoprotein to form β2-GPI-ox-LDL complexes, and serum levels of β2-GPI-ox-LDL complexes were significantly elevated in autoimmune disorders, which may reliably help to predict the development of autoimmune-mediated atherosclerosis [22]. This evidence concerns the gene APOH and autoimmune disease.