IGHE and chronic rhinosinusitis without nasal polyps: Furthermore, in a recent study of inflammatory endotypes and phenotypes of CRS, CRSwNP, and CRSsNP, based on cluster analysis of biomarkers, Tomassen et al. demonstrated that high expression of IL-5 and the presence of S. aureus enterotoxin-specific IgE (SE-IgE) were both observed in patients with CRSwNP, but not in those with CRSsNP [8].