IL25 and chronic rhinosinusitis with nasal polyps: Furthermore, profibrotic cytokines and fibrogenic mediators, such as IL-11, IL-17, IL-17E (also known as IL-25), TGF-α, TGFβ1, and matrix metalloproteinase-9, are involved in airway remodeling in asthma [4] and polyp formation in CRS with nasal polyps (CRSwNP) [5].