Regarding mechanisms of CRSwNP development, Bachert et al. previously reported that both orchestration by Th2 cytokines and amplification by Staphylococcus aureus enterotoxin B (SEB), a S. aureus superantigen, are required for the formation of nasal polyps with eosinophilia [7]. Here, SETBP1 is linked to Nasal polyposis.