Genistein administration in NASH rats induced by a high fat diet alleviated liver damage through inhibition of inflammatory processes by reducing serum levels of TNF-α and IL-6 and inhibiting IκB-α phosphorylation, nuclear translocation of NF-κB p65 subunit, and activation of c-Jun N-terminal kinase (JNK) [98]. This evidence concerns the gene IL6 and metabolic dysfunction-associated steatohepatitis.