Flavonoids such as isoflavones and their metabolites also induce cancer cell apoptosis in cells derived from human gastric cancer [50] by inhibiting DNA topoisomerase I/II activity, decreased production of ROS, regulation of heat shock protein expression, modulation of signaling pathways, suppression of NF-κB, activation of endonuclease, and suppression of Mcl-1 protein. Here, NFKB1 is linked to cancer.