To test whether this vaccination strategy is also effective for melanoma-associated Ags, tyrosine-related protein 1 (Trp1), Trp2, gp100 and MelanA recognized by T cells 1 (MART-1-) derived peptides were conjugated to Abs specific for mouse CD169 (MOMA-1), DEC205 (NLDC-145) or an isotype control (R7D4). The gene discussed is DDX41; the disease is melanoma.