Anti-fibrillarin antibodies have been detected in a variety of connective tissue patients like the mixed connective tissue diseases (60%), CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia syndrome, 58%), systemic lupus erythematosus (39%), rheumatoid arthritis (60%), and Sjogern’s syndrome (84%), in addition to SSc patients (58%) [129,130]. Here, FBL is linked to systemic sclerosis.