IL6 and neoplasm: CAFs produce most of the extracellular matrix, highly abundant in PDAC, but they also favor tumor growth and metastases by secreting inflammatory cytokines, mainly IL-6; chemokines; and chemokines ligands, namely CCL2 and C–X–C motif chemokine ligand 12 (CXCL12) [63,73,74,75].