In ASD cases with epilepsy or tics, 25.81% and 9.68% carried rare functional variants in CNTNAP2 and MEF2C, respectively, whereas in ASD cases without epilepsy or tics, only 2.78% and 0% carried rare functional variants in CNTNAP2 and MEF2C, respectively. Here, CNTNAP2 is linked to tic disorder.