Data sources for the model inputs, calibration and validation included: the National Patient Register (including data on cancer treatment), National Prostate Register (cancer incidence by Gleason score, T-stage and M-stage), Total Population Register (defining the at-risk population), Cause of Death Register, the Stockholm PSA and Biopsy Register (SPBR), and the PCBaSe research database for prostate cancer survival. Here, KLK3 is linked to Familial prostate cancer.