As previous studies examining plasma levels of BNP in association with AD-related cognitive decline reported results that are in disagreement with each other [26, 28], in this study, we investigated whether plasma measurements of BNP, that were obtained by using a novel, indirect approach for plasma peptide/protein detection called a SOMAscan [31], may predict a decline in cognitive function which occurs during AD progression. Here, NPPB is linked to Mental deterioration.