CD8A and HIV infectious disease: HIV infection accounted for lower CD4+ and CD8+ Tscm frequencies compared to uninfected controls (CD4+ Tscm; HIV+, T0: 2.9% IQR: 1.1–9.1; HIV-: 5.2% IQR: 3.6–12; p = 0.04; Fig 3A; CD8+ Tscm; HIV+, T0: 1.4% IQR: 0.7–2.5; HIV-: 3.7% IQR: 2.2–6.5; p = 0.002; Fig 3B).