We show here that P. luminescens ΔmdtA is as virulent as the wild-type strain after injection into haemocoel of the locust and the lepidopterans Spodoptera. These findings were expected given that Photorhabdus has a plenty of different and redundant virulence factors ranging from potent toxins and enzymes to PhoP-regulated LPS modification systems mediating resistance to AMPs produced in insect haemolymph upon infection [9]. This evidence concerns the gene ADSL and infection.