As shown in Table 2, among women with an age at first birth >23 years the risk of breast cancer increased with increasing quartiles of LUMA methylation (ORQ2 vs Q1 = 1.06, 95%CI = 0.74–1.51; ORQ3 vs Q1 = 1.78, 95%CI = 1.28–2.47; ORQ4 vs Q1 = 2.62, 95%CI = 1.90–3.62). This evidence concerns the gene TMEM43 and breast cancer.