There was no significant change in IL-6 or IL-8 levels from the acute episode period to the remission period of BD (P >.05; Fig. 4D and E); moreover, no significant changes were observed in IL-6, IL-8, and CRP levels from the acute episode period to the remission period of MDD (P >.05; Fig. 4A, B, and C). This evidence concerns the gene IL6 and major depressive disorder.