We found that serum IL-6 levels showed significant elevation in both depressive (4.379 ± 0.3587 vs 2.141 ± 0.3164, P <.01; Fig. 2A) and manic/mixed (3.972 ± 0.7454 vs 2.141 ± 0.3164, P <.05; Fig. 2B) BD patients. The gene discussed is IL6; the disease is Behcet disease.