An ideal prognostic biomarker should match 2 features: accurate measurability and definite association with either pathologic progression or prognosis.[43] SEMA4D are widely utilized in clinical pathology examination to auxiliary diagnose neurogenic tumor.[44] Substantial evidence demonstrated that SEMA4D was involved in angiogenesis, regulation of tumor microenvironment and cancer progression of various types of tumors. The gene discussed is SEMA4D; the disease is cancer.