Moreover, SEMA4D regulates tumor environment by inhibiting monocyte migration and prompting monocyte differentiation to M2 macrophages which acts as a tumor-promotor.[41] Chen's study[41] showed a strong association between SEMA4D expression and M2 macrophages count both in epithelial ovarian cancer (EOC) tumor sample and in malignant ascites. Here, SEMA4D is linked to neoplasm.