Because all 6 studies assessed SEMA4D expression from tumor tissue by immunohistochemistry staining and reported the HRs/RRs, IHC group, tissue group and reported HRs/RRs group had a same result as the total DFS/PFS/RFS analysis (HR = 1.59, 95%CI: 1.27–1.98, P < .001) (Supplemental figures 6–8). This evidence concerns the gene SEMA4D and neoplasm.