Interestingly, all 4 articles of Plexin-B1 group focused on breast cancer research, and SEMA4D group showed a wide variety of malignant tumors including prostate cancer, colorectal cancer (CRC), soft tissue sarcoma (STS), epithelial ovarian cancer (EOC), breast cancer, cervical cancer, and pancreatic cancer. This evidence concerns the gene PLXNB1 and colorectal carcinoma.