Interestingly, all 4 articles of Plexin-B1 group focused on breast cancer research, and SEMA4D group showed a wide variety of malignant tumors including prostate cancer, colorectal cancer (CRC), soft tissue sarcoma (STS), epithelial ovarian cancer (EOC), breast cancer, cervical cancer, and pancreatic cancer. The gene discussed is PLXNB1; the disease is familial pancreatic carcinoma.