In the rh‐endostatin 7d group, a total of 16 cases (59.3%) of adverse reactions occurred, and 3 cases (11.1%) of serious adverse events, including 1 case of grade 4 thrombocytopenia (3.7%), 1 case of nausea (3.7%), and 1 case of vomiting (3.7%). The gene discussed is COL18A1; the disease is Thrombocytopenia.