Our study shows that SSRP1 promotes CRC progression, which agrees with previous studies in other types of cancers, such as nonsmall cell lung cancer,30 breast cancer13, 31 and hepatic carcinoma (HCC).23 Significantly shortened survival is observed in patients with high SSRP1 expression compared with patients with low SSRP1 expression. This evidence concerns the gene SSRP1 and hepatocellular carcinoma.