MicroRNAs (miRNAs) are small noncoding RNA molecules that are highly conserved and can induce mRNA cleavage or repress translation by targeting the 3’UTR of corresponding mRNAs.19, 20, 21 Recently, an increasing number of studies have reported that miRNAs can regulate various cellular processes in cancer, such as proliferation, apoptosis, metastasis and chemoresistance.20 In this study, we have been suggested that the abnormal expression of SSRP1 in CRC is partly due to the upstream dysregulation of miRNAs. The gene discussed is SSRP1; the disease is colorectal carcinoma.