CDKN1A and colorectal carcinoma: We found that the siRNA‐induced knockdown of SSRP1 significantly inhibited cell cycle progression from G0/G1 phase to S phase in CRC cells, resulting in G1 cell cycle arrest due to the reduction in cyclin D1 and 14‐3‐3 expression and the increase in p53, p21 and p27 expression.