MAPT and Parkinson disease: Degenerative parkinsonian disorders can be broadly divided into two groups based on neuropathological characteristics: (1) synucleinopathies, which includes PD with dementia (PDD), dementia with Lewy bodies (DLB) and multiple system atrophies (MSAs); and (2) tauopathies, including progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), associated with intra-neuronal and astrocytic aggregates of tau.