Insulin resistance may lead to glucose metabolism dysregulation (Arrieta‐Cruz & Gutiérrez‐Juárez, 2016), additionally, thyroid disorder including both hyperthyroid and hypothyroid are associated with insulin resistance (Kapadia, Bhatt, & Shah, 2012), we may hypothesize that the potential insulin signaling pathway is involved in the actions of brain hypothyroidism on weakening glycolysis in BPA–treated animals. The gene discussed is INS; the disease is thyroid gland disorder.