Insulin resistance may lead to glucose metabolism dysregulation (Arrieta‐Cruz & Gutiérrez‐Juárez, 2016), additionally, thyroid disorder including both hyperthyroid and hypothyroid are associated with insulin resistance (Kapadia, Bhatt, & Shah, 2012), we may hypothesize that the potential insulin signaling pathway is involved in the actions of brain hypothyroidism on weakening glycolysis in BPA–treated animals. This evidence concerns the gene INS and Insulin resistance.