Remarkably, the ovarian cyst also had a second likely pathogenic variant in PIK3CA, c.2135 T>C (p.(Leu712Pro), VAF <10%), and a third likely pathogenic variant in CDKN1C, c.167A>G (p.(Glu56Gly), VAF 36%–45%). Here, PIK3CA is linked to Ovarian cyst.