Remarkably, the ovarian cyst also had a second likely pathogenic variant in PIK3CA, c.2135 T>C (p.(Leu712Pro), VAF <10%), and a third likely pathogenic variant in CDKN1C, c.167A>G (p.(Glu56Gly), VAF 36%–45%). The gene discussed is CDKN1C; the disease is Ovarian cyst.