NR1H4 and liver failure: Bile acid receptors such as farnesoid X receptor (FXR) promote liver regeneration and prevent liver failure by (i) modulating the bile acid pool size, composition, and compartmentalization [21,26], (ii) governing the production of mitogens such as fibroblast growth factor 15/19 (FGF15/19, signifying rodent/human orthologues) [22,23], and (iii) rewiring mitochondrial metabolism to fuel liver growth [27].