FH and familial hyperaldosteronism: The rise of polygenic risk scores presents intriguing possibilities for FH management, including facilitating the recognition of polygenic FH in phenotype-positive patients without monogenic mutations, and assessing additive ASCVD risk in monogenic variant-positive patients to identify an “extremely high-risk” population that may benefit from early initiation of advanced FH therapies such as PCKS9 inhibitors for primary prevention.