Two fully human anti-PCSK9 monoclonal antibodies (MAbs), alirocumab (SAR236553/REGN727 from Regeneron Pharmaceuticals/Sanofi) and evolocumab (AMG145 by Amgen), are currently approved for the treatment of hypercholesterolemia by the US Food and Drug Administration and European Medicines Agency. This evidence concerns the gene PCSK9 and familial hypercholesterolemia.