ABCB1 and lung adenocarcinoma: For example, KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) was closely associated with insensitivity of lung adenocarcinoma, and also knockdown of KCNQ1OT1 depressed the expression level of Multidrug Resistance Protein 1 (MDR1) and the paclitaxel resistance (28).