In accordance, correlation analysis showed that EYA2 mRNA was inversely correlated with the mRNA levels of luminal markers ESR1, PGR and FOXA1, and positively associated with TNBC markers KRT5, KRT6B, and EGFR. In consistence, it was reported that EGFR positively regulated EYA2 through the regulation of microRNA-338-3P to promote breast tumor growth and metastasis (18). The gene discussed is ESR1; the disease is breast neoplasm.