21 showed that sorafenib‐resistant HCC cells demonstrated induction of HGF synthesis and secretion, as well as increased levels of MET kinase activation, which indicated an autocrine activation of HGF/MET signaling. Han et al. 22 also reported HGF overexpression and enhanced MET activation in sorafenib‐resistant HCC cells. Here, HGF is linked to hepatocellular carcinoma.