STAT3 and neoplasm: In HCC, regorafenib induces significant tumor inhibition and induces extrinsic and intrinsic apoptosis via the inhibition of signal transducer and activator of transcription 3 (STAT3) and the extracellular signal‐related kinase (ERK)/nuclear factor‐kappa B (NF&kgr;B) pathways 15, 16, 17.