In addition, although transgenic overexpression of leptin and fat transplantation rescued the metabolic disorders in lipoatrophic AZIPtg/+ mice 16, 17, the transplantation of adipose tissue from ob/ob mice was unable to reverse AZIPtg/+ diabetes phenotype, thus underlying the fundamental role of leptin and its signaling in maintaining body homeostasis 18. Here, LEP is linked to diabetes mellitus.