Two significantly enriched pathways in LUAD and their related DEmRNAs, namely transcriptional misregulation in cancer (TGFBR2, FLI1, ERG and SIX1) and central carbon metabolism (NTRK3 and SLC7A5), were speculated to play key roles in LUAD regulated by DEmiRNAs. This evidence concerns the gene SLC7A5 and cancer.