The migration results suggested that the ESCC cells were more vulnerable to the overactivation of TRPV1 and TRPV4 channels than the nontumor esophageal squamous cells and these effects may result from the higher expression levels of thermo‐TRPVs among ESCC cells (Fig. 1B,C) or different signal pathways exploited by the 2 different types of cells during the activation process. Here, TRPV1 is linked to esophageal squamous cell carcinoma.