NSD2 and Miyoshi myopathy: By contrast, in t(4;14)-positive MM the enhanced expression of the H3K36 methyltransferase NSD2 changes the balance between the H3K26me2 and H3K27me3 resulting in increased levels of H3K36me2 and a striking decrease in H3K27me3 levels [57,58] NSD2 functions as an oncogene in MM and its overexpression restored the tumorigenicity of t(4;14)-negative MM cells.