IKZF3 and Miyoshi myopathy: The current treatment strategies are focused on killing the malignant PCs by induction of wide-range stress responses utilizing proteasome inhibitors (bortezomib) and histone deacetylase (HDAC) inhibitors (Valproic acid), or by more specific targeting agent such as immunomodulatory drugs (thalidomide and lenalidomide) to deprive the MM cells of key oncogenic transcription factors (e.g., Ikaros (IKZF1) and Aiolos (IKZF3) [36,41–43]).