EZH2 and Miyoshi myopathy: Moreover, EZH2 overexpression was suggested to be indicative of poor prognosis in MM i.e., shortened progression-free and overall survival, as well as reduced median overall survival based on multivariate analysis in two large independent data sets of phase III clinical trial patients, MyIX (n = 259) and UAMS-TT (n = 123) [88].