EZH2 and Miyoshi myopathy: In 2010, we showed that EZH2/PRC2 inhibition using the broadly acting S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin (DZNep) and the histone deacetylase inhibitor LBH589 (Panobinostat) depletes EZH2 and other PRC2 components from cells and demonstrated anti-MM effects using HMCLs in vitro and in the 5T33MM in vivo models [87].