Despite an initial phase I clinical trial (NCT02082977) using EZH2 inhibitors as single agent treatment has shown insufficient evidence of clinical activity, the use of EZH2 inhibitors in combination with current treatment protocols such as proteasome inhibitors, IMiDs, and dexamethasone may provide a therapeutic value for MM patients, especially for relapsed/refractory groups of MM patients. Here, EZH2 is linked to Miyoshi myopathy.