Notably, the EZH2 specific inhibitor GSK126 as well as the HDAC1 inhibitor MC1294 reversed the repressive chromatin architecture at Runx2 promoter and thereby rescued osteoblast differentiation in osteoblast precursors exposed to MM cells in vitro or in osteoblast precursors from MM patients [128]. Here, EZH2 is linked to Miyoshi myopathy.