Renner et al. (2007) have observed that eIF4G phosphorylation was increased in the prostate of transgenic mice expressing a constitutively active p110-alpha catalytic subunit of PI3K. Consistently, inhibition of PI3K activity with the drug LY294002 inhibited eIF4G phosphorylation. Thus, eIF4G phosphorylation has been proposed as a new marker for PI3K activity in PCa (Renner et al., 2007). Finally, both meta-analysis and immunoblot of tissue extracts showed that eIF4G is overexpressed in human PCa epithelial tissue (Wang et al., 2005). Here, PIK3CA is linked to posterior cortical atrophy.