Tightly related to cancer development, these so-called “eIF4E-sensitive” transcripts encode proteins that stimulate cell survival and proliferation, such as vascular endothelial growth factor-A (VEGF-A), hypoxia inducible factor 1 alpha (HIF1-α), BCL-2 family members, ornithine decarboxylase 1 (ODC1), cyclin D3, and c-MYC (Feoktistova et al., 2013; Truitt et al., 2015; Hinnebusch et al., 2016; Truitt and Ruggero, 2016; Vaklavas et al., 2017). The gene discussed is VEGFA; the disease is cancer.