Multiple transgenic mouse models show that overexpression of FGF2, FGF3, FGF7, or FGF8 in prostate epithelial cells lead to prostatic lesions, ranging from low grade PIN, high-grade PIN to PCa (Chua et al., 2002; Foster et al., 2002; Song et al., 2002; Konno-Takahashi et al., 2004). Here, FGF8 is linked to prostate intraepithelial neoplasia.