Loss of FGF7/FGF10 diminishes the homeostasis promoting function of FGFR2IIIb is also common during PCa progression (Yan et al., 1992; Lu et al., 1999; Wang, 2011; Wang et al., 2013; Li et al., 2016), which, together with gain of FGF2 that activates ectopic FGFR1IIIc, contributes to PCa progression (Figure 1). The gene discussed is FGF10; the disease is posterior cortical atrophy.