Conditional ablation of Frs2α alleles in prostate epithelial cells represses PCa initiation and progression, as evidenced by fewer and lower grade of PIN lesion foci at early stages, less advanced tumors at mid stages, and a longer lifespan of Frs2α conditional null TRAMP than that of parental TRAMP mice (Zhang et al., 2008). The gene discussed is FRS2; the disease is posterior cortical atrophy.