In addition, expression of dnFGFR2 potentiates the development and progression of prostatic intraepithelial neoplasia (PIN) lesions induced by expression of ectopic FGFR1 kinase, demonstrating the cooperation between ablation of resident FGFR2 and expression of ectopic FGFR1 in promoting PCa progression (Jin et al., 2003; Wang et al., 2004). This evidence concerns the gene FGFR1 and prostate intraepithelial neoplasia.