Phenotypically, tumor primed NK cells appear distinct from resting NK cells in that they exhibit reduced expression of activating receptors (e.g., CD16, NKG2D, NKp46), both in terms of intensity and proportion, whereas both the proportion and intensity of expression of co-receptors (e.g., CD69 and CD25) are up-regulated (19, 20). This evidence concerns the gene NCR1 and neoplasm.